59.3 B12

59.3.1 Global tests

Type III ANOVA on main and interaction effects, and LM model summaries.

Prolactin
Chisq Df Pr(>Chisq)
(Intercept) 142.6249156 1 <0.0001 ***
B12 0.0133596 1 0.9 ns
GDM_new 2.0584988 1 0.2 ns
Study 0.2833550 1 0.6 ns
GA_samp 153.0273355 1 <0.0001 ***
B12:GDM_new 1.2736316 1 0.3 ns
GDM_new:Study 1.6999725 1 0.2 ns
B12:Study 0.2217536 1 0.6 ns
B12:GDM_new:Study 0.7321150 1 0.4 ns
HPL
Chisq Df Pr(>Chisq)
(Intercept) 27.4857978 1 <0.0001 ***
B12 1.0580423 1 0.3 ns
GDM_new 6.0339287 1 0.01 *
Study 3.7853360 1 0.05 ns
GA_samp 1979.9428441 1 <0.0001 ***
B12:GDM_new 3.8688047 1 0.05 ns
GDM_new:Study 7.9375646 1 0.005 **
B12:Study 0.0272714 1 0.9 ns
B12:GDM_new:Study 6.5247527 1 0.01 *
GH2
Chisq Df Pr(>Chisq)
(Intercept) 343.0252955 1 <0.0001 ***
B12 6.3264944 1 0.01 *
GDM_new 3.1930263 1 0.07 ns
Study 0.7898003 1 0.4 ns
GA_samp 898.0854142 1 <0.0001 ***
B12:GDM_new 1.2319261 1 0.3 ns
GDM_new:Study 2.8650730 1 0.09 ns
B12:Study 1.7622600 1 0.2 ns
B12:GDM_new:Study 0.9244163 1 0.3 ns
Insulin
model term df1 df2 F.ratio Chisq p.value
1 B12 1 Inf 6.372 6.372 0.01 *
5 GDM_new 1 Inf 12.913 12.913 0.0003 ***
7 Study 1 Inf 7.038 7.038 0.008 **
8 GA_samp 1 Inf 0.018 0.018 0.9 ns
2 B12:GDM_new 1 Inf 1.272 1.272 0.3 ns
4 B12:Study 1 Inf 1.629 1.629 0.2 ns
6 GDM_new:Study 1 Inf 0.909 0.909 0.3 ns
3 B12:GDM_new:Study 1 Inf 0.302 0.302 0.6 ns
HOMA.IR
model term df1 df2 F.ratio Chisq p.value
1 B12 1 Inf 4.974 4.974 0.03 *
5 GDM_new 1 Inf 11.314 11.314 0.0008 ***
7 Study 1 Inf 8.376 8.376 0.004 **
8 GA_samp 1 Inf 0.010 0.010 0.9 ns
2 B12:GDM_new 1 Inf 0.879 0.879 0.3 ns
4 B12:Study 1 Inf 1.091 1.091 0.3 ns
6 GDM_new:Study 1 Inf 0.677 0.677 0.4 ns
3 B12:GDM_new:Study 1 Inf 0.121 0.121 0.7 ns
GLUC3_mmol.L
model term df1 df2 F.ratio Chisq p.value
1 B12 1 Inf 0.355 0.355 0.6 ns
5 GDM_new 1 Inf 0.786 0.786 0.4 ns
7 Study 1 Inf 8.298 8.298 0.004 **
8 GA_samp 1 Inf 0.579 0.579 0.4 ns
2 B12:GDM_new 1 Inf 0.044 0.044 0.8 ns
4 B12:Study 1 Inf 0.073 0.073 0.8 ns
6 GDM_new:Study 1 Inf 0.267 0.267 0.6 ns
3 B12:GDM_new:Study 1 Inf 0.010 0.010 0.9 ns

59.3.2 Model summary

Ratio of Geometric means (95% CI)

Prolactin
Var Effect P
(Intercept) 2.58 (2.16, 3.01) <0.0001
B12 0.00 (-0.00, 0.00) 0.72
GDM_newGDM -0.21 (-0.49, 0.08) 0.16
StudySTOP -0.04 (-0.26, 0.19) 0.76
GA_samp 0.15 (0.13, 0.17) <0.0001
B12:GDM_newGDM 0.00 (-0.00, 0.00) 0.36
GDM_newGDM:StudySTOP 0.16 (-0.06, 0.39) 0.16
B12:StudySTOP 0.00 (-0.00, 0.00) 0.84
HPL
Var Effect P
(Intercept) 0.59 (0.37, 0.81) <0.0001
B12 0.00 (-0.00, 0.00) 0.30
GDM_newGDM -0.36 (-0.65, -0.07) 0.01
StudySTOP 0.12 (-0.00, 0.24) 0.05
GA_samp 0.29 (0.28, 0.31) <0.0001
B12:GDM_newGDM 0.00 (0.00, 0.00) 0.05
GDM_newGDM:StudySTOP 0.46 (0.14, 0.78) 0.005
B12:StudySTOP 0.00 (-0.00, 0.00) 0.87
B12:GDM_newGDM:StudySTOP -0.00 (-0.00, -0.00) 0.01
GH2
Var Effect P
(Intercept) -2.77 (-3.07, -2.48) <0.0001
B12 0.00 (0.00, 0.00) 0.004
GDM_newGDM -0.21 (-0.42, 0.00) 0.05
StudySTOP 0.10 (-0.06, 0.26) 0.24
GA_samp 0.26 (0.25, 0.28) <0.0001
B12:GDM_newGDM 0.00 (-0.00, 0.00) 0.56
GDM_newGDM:StudySTOP 0.19 (0.03, 0.36) 0.02
B12:StudySTOP -0.00 (-0.00, 0.00) 0.09
Insulin
Var Effect P
(Intercept) 2.87 (2.29, 3.46) <0.0001
B12 -0.00 (-0.00, 0.00) 0.05
GDM_newGDM 0.97 (0.54, 1.40) <0.0001
StudySTOP -0.49 (-0.81, -0.16) 0.004
GA_samp 0.00 (-0.03, 0.04) 0.89
B12:GDM_newGDM -0.00 (-0.00, 0.00) 0.27
GDM_newGDM:StudySTOP -0.25 (-0.58, 0.08) 0.14
B12:StudySTOP 0.00 (-0.00, 0.00) 0.20
HOMA.IR
Var Effect P
(Intercept) 1.51 (0.89, 2.13) <0.0001
B12 -0.00 (-0.00, 0.00) 0.07
GDM_newGDM 1.07 (0.59, 1.55) <0.0001
StudySTOP -0.64 (-0.99, -0.29) 0.0004
GA_samp -0.00 (-0.04, 0.03) 0.92
B12:GDM_newGDM -0.00 (-0.00, 0.00) 0.29
GDM_newGDM:StudySTOP -0.31 (-0.67, 0.06) 0.10
B12:StudySTOP 0.00 (-0.00, 0.00) 0.23
GLUC3_mmol.L
Var Effect P
(Intercept) 1.76 (1.64, 1.87) <0.0001
B12 -0.00 (-0.00, 0.00) 0.19
GDM_newGDM 0.11 (-0.04, 0.26) 0.16
StudySTOP -0.16 (-0.22, -0.10) <0.0001
GA_samp -0.00 (-0.01, 0.00) 0.45
B12:GDM_newGDM 0.00 (-0.00, 0.00) 0.80
GDM_newGDM:StudySTOP -0.08 (-0.20, 0.03) 0.15
B12:StudySTOP 0.00 (-0.00, 0.00) 0.52

59.3.3 Estimated means

Estimated marginal means (or adjusted means) adjusted for GA at sampling.

Results are averaged over the levels of B12 concentration (pM) and may be misleading when interaction term is involved.

Prolactin
Study GDM_new response SE df lower.CL upper.CL
SCOPE Uncomplicated 95.12747 7.791555 108.87662 80.87298 111.8944
STOP Uncomplicated 93.83962 7.020651 76.25041 80.84932 108.9171
SCOPE GDM 86.24608 10.930774 483.07616 67.23380 110.6346
STOP GDM 100.23681 8.826828 141.47889 84.22169 119.2973
HPL
Study GDM_new response SE df lower.CL upper.CL
SCOPE Uncomplicated 86.68206 2.632632 213.4706 81.64505 92.02982
STOP Uncomplicated 98.85500 2.509604 106.3658 94.00280 103.95767
SCOPE GDM 82.65049 4.849031 610.8268 73.65582 92.74357
STOP GDM 95.63783 3.401521 314.8558 89.17405 102.57015
GH2
Study GDM_new response SE df lower.CL upper.CL
SCOPE Uncomplicated 2.304977 0.0803862 513.1083 2.152340 2.468440
STOP Uncomplicated 2.219625 0.0577786 208.4185 2.108593 2.336504
SCOPE GDM 1.970136 0.1533418 1081.8609 1.691104 2.295208
STOP GDM 2.296205 0.0948462 488.7588 2.117210 2.490332
Insulin
Study GDM_new response SE df asymp.LCL asymp.UCL
SCOPE Uncomplicated 13.55675 0.9031283 Inf 11.89734 15.44761
STOP Uncomplicated 10.35361 0.4308209 Inf 9.54273 11.23339
SCOPE GDM 29.66964 4.3870159 Inf 22.20505 39.64357
STOP GDM 17.64377 1.3367027 Inf 15.20911 20.46817
HOMA.IR
Study GDM_new response SE df asymp.LCL asymp.UCL
SCOPE Uncomplicated 3.289451 0.2333498 Inf 2.862465 3.780129
STOP Uncomplicated 2.157247 0.0942625 Inf 1.980186 2.350140
SCOPE GDM 7.863563 1.2846270 Inf 5.709042 10.831173
STOP GDM 3.797184 0.3091261 Inf 3.237173 4.454073
GLUC3_mmol.L
Study GDM_new response SE df asymp.LCL asymp.UCL
SCOPE Uncomplicated 5.403450 0.0734390 Inf 5.261413 5.549322
STOP Uncomplicated 4.707016 0.0423890 Inf 4.624664 4.790834
SCOPE GDM 6.076550 0.3186762 Inf 5.482984 6.734373
STOP GDM 4.865341 0.0638087 Inf 4.741872 4.992025

59.3.4 Comparisons

59.3.4.1 Within Groups

Effect for every 100 unit increase in B12 concentration (pM).
Hormone Contrast Study GDM_new Ratio of Geometric means (95% CI) P-value
Prolactin B12366 / B12266 SCOPE Uncomplicated 1.010 (0.956, 1.067) 0.7
Prolactin B12366 / B12266 STOP Uncomplicated 1.017 (0.978, 1.058) 0.4
Prolactin B12366 / B12266 SCOPE GDM 1.045 (0.958, 1.140) 0.3
Prolactin B12366 / B12266 STOP GDM 1.052 (0.986, 1.123) 0.1
HPL B12366 / B12266 SCOPE Uncomplicated 1.016 (0.986, 1.047) 0.3
HPL B12366 / B12266 STOP Uncomplicated 1.019 (0.997, 1.041) 0.08
HPL B12366 / B12266 SCOPE GDM 1.122 (1.021, 1.233) 0.02
HPL B12366 / B12266 STOP GDM 0.977 (0.942, 1.015) 0.2
GH2 B12366 / B12266 SCOPE Uncomplicated 1.060 (1.018, 1.103) 0.004
GH2 B12366 / B12266 STOP Uncomplicated 1.016 (0.987, 1.045) 0.3
GH2 B12366 / B12266 SCOPE GDM 1.077 (1.011, 1.148) 0.02
GH2 B12366 / B12266 STOP GDM 1.032 (0.984, 1.083) 0.2
Insulin B12366 / B12266 SCOPE Uncomplicated 0.911 (0.830, 1.000) 0.05
Insulin B12366 / B12266 STOP Uncomplicated 0.976 (0.925, 1.029) 0.4
Insulin B12366 / B12266 SCOPE GDM 0.858 (0.751, 0.980) 0.02
Insulin B12366 / B12266 STOP GDM 0.919 (0.835, 1.011) 0.08
HOMA.IR B12366 / B12266 SCOPE Uncomplicated 0.910 (0.824, 1.006) 0.07
HOMA.IR B12366 / B12266 STOP Uncomplicated 0.975 (0.920, 1.034) 0.4
HOMA.IR B12366 / B12266 SCOPE GDM 0.856 (0.741, 0.987) 0.03
HOMA.IR B12366 / B12266 STOP GDM 0.917 (0.827, 1.016) 0.10
GLUC3_mmol.L B12366 / B12266 SCOPE Uncomplicated 0.989 (0.973, 1.005) 0.2
GLUC3_mmol.L B12366 / B12266 STOP Uncomplicated 0.996 (0.986, 1.005) 0.4
GLUC3_mmol.L B12366 / B12266 SCOPE GDM 0.992 (0.960, 1.026) 0.7
GLUC3_mmol.L B12366 / B12266 STOP GDM 0.999 (0.978, 1.020) 0.9

59.3.4.2 Between Groups

Below are comparisons of the differences in the change in B12 concentration (pM) between groups. I.e. whether the change in B12 concentration (pM) are different between groups.

Prolactin
contrast ratio SE df lower.CL upper.CL p.value
SCOPE/SCOPE (Overall) 1.013692 0.0682250 1341.524 0.8883123 1.156769 0.840 ns
STOP/SCOPE (Uncomplicated) 1.006823 0.0338813 1341.524 0.9425032 1.075532 0.840 ns
STOP/SCOPE (GDM) 1.006823 0.0338813 1341.524 0.9425032 1.075532 0.840 ns
GDM/Uncomplicated (SCOPE) 1.034630 0.0387836 1372.494 0.9612779 1.113578 0.364 ns
GDM/Uncomplicated (STOP) 1.034630 0.0387836 1372.494 0.9612779 1.113578 0.364 ns
HPL
contrast ratio SE df lower.CL upper.CL p.value
SCOPE/SCOPE (Overall) 0.8739563 0.0481123 664.0487 0.7844125 0.9737219 0.015 *
STOP/SCOPE (Uncomplicated) 1.0031428 0.0190608 1300.0835 0.9664378 1.0412418 0.869 ns
STOP/SCOPE (GDM) 0.8712183 0.0450833 600.1575 0.7870286 0.9644139 0.008 **
GDM/Uncomplicated (SCOPE) 1.1042956 0.0556984 563.4220 1.0001384 1.2193001 0.050 *
GDM/Uncomplicated (STOP) 0.9590684 0.0210968 1400.5208 0.9185638 1.0013591 0.058 ns
GH2
contrast ratio SE df lower.CL upper.CL p.value
SCOPE/SCOPE (Overall) 0.9187595 0.0451804 1392.880 0.8342711 1.011804 0.085 ns
STOP/SCOPE (Uncomplicated) 0.9585194 0.0235678 1392.880 0.9133844 1.005885 0.085 ns
STOP/SCOPE (GDM) 0.9585194 0.0235678 1392.880 0.9133844 1.005885 0.085 ns
GDM/Uncomplicated (SCOPE) 1.0164068 0.0280875 1431.273 0.9627764 1.073025 0.556 ns
GDM/Uncomplicated (STOP) 1.0164068 0.0280875 1431.273 0.9627764 1.073025 0.556 ns
Insulin
contrast ratio SE df asymp.LCL asymp.UCL p.value
SCOPE/SCOPE (Overall) 1.1469112 0.1224671 Inf 0.9303332 1.413908 0.199 ns
STOP/SCOPE (Uncomplicated) 1.0709394 0.0571774 Inf 0.9645378 1.189078 0.199 ns
STOP/SCOPE (GDM) 1.0709394 0.0571774 Inf 0.9645378 1.189078 0.199 ns
GDM/Uncomplicated (SCOPE) 0.9414962 0.0512245 Inf 0.8462658 1.047443 0.268 ns
GDM/Uncomplicated (STOP) 0.9414962 0.0512245 Inf 0.8462658 1.047443 0.268 ns
HOMA.IR
contrast ratio SE df asymp.LCL asymp.UCL p.value
SCOPE/SCOPE (Overall) 1.1477984 0.1316612 Inf 0.9166981 1.437159 0.229 ns
STOP/SCOPE (Uncomplicated) 1.0713535 0.0614462 Inf 0.9574435 1.198816 0.229 ns
STOP/SCOPE (GDM) 1.0713535 0.0614462 Inf 0.9574435 1.198816 0.229 ns
GDM/Uncomplicated (SCOPE) 0.9398504 0.0551365 Inf 0.8377662 1.054374 0.290 ns
GDM/Uncomplicated (STOP) 0.9398504 0.0551365 Inf 0.8377662 1.054374 0.290 ns
GLUC3_mmol.L
contrast ratio SE df asymp.LCL asymp.UCL p.value
SCOPE/SCOPE (Overall) 1.013107 0.0205779 Inf 0.9735669 1.054252 0.521 ns
STOP/SCOPE (Uncomplicated) 1.006532 0.0102222 Inf 0.9866950 1.026768 0.521 ns
STOP/SCOPE (GDM) 1.006532 0.0102222 Inf 0.9866950 1.026768 0.521 ns
GDM/Uncomplicated (SCOPE) 1.003341 0.0130778 Inf 0.9780336 1.029303 0.798 ns
GDM/Uncomplicated (STOP) 1.003341 0.0130778 Inf 0.9780336 1.029303 0.798 ns

59.3.5 Estimated means (50 unit increase)

Estimated marginal means (or adjusted means) adjusted for GA at sampling.

Results are averaged over the levels of B12 concentration (pM) and may be misleading when interaction term is involved.

Prolactin
Study GDM_new response SE df lower.CL upper.CL
SCOPE Uncomplicated 94.89006 7.689011 104.38962 80.80501 111.4303
STOP Uncomplicated 93.44643 6.980985 75.81143 80.52703 108.4386
SCOPE GDM 85.30174 10.708996 469.99571 66.65305 109.1681
STOP GDM 98.97089 8.685380 139.61786 83.20617 117.7225
HPL
Study GDM_new response SE df lower.CL upper.CL
SCOPE Uncomplicated 86.33838 2.557415 194.8997 81.43912 91.53238
STOP Uncomplicated 98.38586 2.489064 104.9517 93.57222 103.44712
SCOPE GDM 80.30615 4.473273 621.1605 71.98499 89.58919
STOP GDM 96.18367 3.397694 307.3219 89.72505 103.10720
GH2
Study GDM_new response SE df lower.CL upper.CL
SCOPE Uncomplicated 2.271758 0.0764773 464.7386 2.126337 2.427125
STOP Uncomplicated 2.210930 0.0572560 204.9840 2.100877 2.326747
SCOPE GDM 1.933858 0.1486430 1066.7735 1.663122 2.248668
STOP GDM 2.277922 0.0931829 478.3484 2.101989 2.468581
Insulin
Study GDM_new response SE df asymp.LCL asymp.UCL
SCOPE Uncomplicated 13.87606 0.8774446 Inf 12.258601 15.70693
STOP Uncomplicated 10.41744 0.4270716 Inf 9.613143 11.28903
SCOPE GDM 30.82962 4.5440752 Inf 23.094412 41.15565
STOP GDM 18.02213 1.3612571 Inf 15.542210 20.89775
HOMA.IR
Study GDM_new response SE df asymp.LCL asymp.UCL
SCOPE Uncomplicated 3.367533 0.2268849 Inf 2.950956 3.842916
STOP Uncomplicated 2.170726 0.0935500 Inf 1.994902 2.362047
SCOPE GDM 8.176041 1.3385987 Inf 5.931746 11.269472
STOP GDM 3.880629 0.3154237 Inf 3.309140 4.550814
GLUC3_mmol.L
Study GDM_new response SE df asymp.LCL asymp.UCL
SCOPE Uncomplicated 5.418350 0.0700905 Inf 5.282702 5.557481
STOP Uncomplicated 4.712319 0.0423122 Inf 4.630114 4.795983
SCOPE GDM 6.088227 0.3250731 Inf 5.483300 6.759891
STOP GDM 4.866762 0.0636995 Inf 4.743501 4.993226

59.3.6 Comparisons (50 unit increase)

59.3.6.1 Within Groups

Effect for every 50 unit increase in B12 concentration (pM).
Hormone Contrast Study GDM_new Ratio of Geometric means (95% CI) P-value
Prolactin B12316 / B12266 SCOPE Uncomplicated 1.005 (0.978, 1.033) 0.7
Prolactin B12316 / B12266 STOP Uncomplicated 1.008 (0.989, 1.028) 0.4
Prolactin B12316 / B12266 SCOPE GDM 1.022 (0.979, 1.068) 0.3
Prolactin B12316 / B12266 STOP GDM 1.026 (0.993, 1.060) 0.1
HPL B12316 / B12266 SCOPE Uncomplicated 1.008 (0.993, 1.023) 0.3
HPL B12316 / B12266 STOP Uncomplicated 1.010 (0.999, 1.021) 0.08
HPL B12316 / B12266 SCOPE GDM 1.059 (1.010, 1.110) 0.02
HPL B12316 / B12266 STOP GDM 0.989 (0.970, 1.007) 0.2
GH2 B12316 / B12266 SCOPE Uncomplicated 1.029 (1.009, 1.050) 0.004
GH2 B12316 / B12266 STOP Uncomplicated 1.008 (0.994, 1.022) 0.3
GH2 B12316 / B12266 SCOPE GDM 1.038 (1.005, 1.071) 0.02
GH2 B12316 / B12266 STOP GDM 1.016 (0.992, 1.041) 0.2
Insulin B12316 / B12266 SCOPE Uncomplicated 0.955 (0.911, 1.000) 0.05
Insulin B12316 / B12266 STOP Uncomplicated 0.988 (0.962, 1.015) 0.4
Insulin B12316 / B12266 SCOPE GDM 0.926 (0.867, 0.990) 0.02
Insulin B12316 / B12266 STOP GDM 0.958 (0.914, 1.005) 0.08
HOMA.IR B12316 / B12266 SCOPE Uncomplicated 0.954 (0.908, 1.003) 0.07
HOMA.IR B12316 / B12266 STOP Uncomplicated 0.988 (0.959, 1.017) 0.4
HOMA.IR B12316 / B12266 SCOPE GDM 0.925 (0.861, 0.994) 0.03
HOMA.IR B12316 / B12266 STOP GDM 0.957 (0.910, 1.008) 0.10
GLUC3_mmol.L B12316 / B12266 SCOPE Uncomplicated 0.995 (0.986, 1.003) 0.2
GLUC3_mmol.L B12316 / B12266 STOP Uncomplicated 0.998 (0.993, 1.003) 0.4
GLUC3_mmol.L B12316 / B12266 SCOPE GDM 0.996 (0.980, 1.013) 0.7
GLUC3_mmol.L B12316 / B12266 STOP GDM 0.999 (0.989, 1.010) 0.9

59.3.6.2 Between Groups

Below are comparisons of the differences in the change in B12 concentration (pM) between groups. I.e. whether the change in B12 concentration (pM) are different between groups.

Prolactin
contrast ratio SE df lower.CL upper.CL p.value
SCOPE/SCOPE (Overall) 1.006823 0.0338813 1341.524 0.9425032 1.075532 0.840 ns
STOP/SCOPE (Uncomplicated) 1.003406 0.0168832 1341.524 0.9708260 1.037079 0.840 ns
STOP/SCOPE (GDM) 1.003406 0.0168832 1341.524 0.9708260 1.037079 0.840 ns
GDM/Uncomplicated (SCOPE) 1.017167 0.0190645 1372.494 0.9804478 1.055262 0.364 ns
GDM/Uncomplicated (STOP) 1.017167 0.0190645 1372.494 0.9804478 1.055262 0.364 ns
HPL
contrast ratio SE df lower.CL upper.CL p.value
SCOPE/SCOPE (Overall) 0.9348563 0.0257325 664.0487 0.8856707 0.9867735 0.015 *
STOP/SCOPE (Uncomplicated) 1.0015702 0.0095155 1300.0835 0.9830757 1.0204126 0.869 ns
STOP/SCOPE (GDM) 0.9333907 0.0241503 600.1575 0.8871463 0.9820458 0.008 **
GDM/Uncomplicated (SCOPE) 1.0508547 0.0265015 563.4220 1.0000692 1.1042192 0.050 *
GDM/Uncomplicated (STOP) 0.9793204 0.0107712 1400.5208 0.9584173 1.0006793 0.058 ns
GH2
contrast ratio SE df lower.CL upper.CL p.value
SCOPE/SCOPE (Overall) 0.9585194 0.0235678 1392.880 0.9133844 1.005885 0.085 ns
STOP/SCOPE (Uncomplicated) 0.9790400 0.0120362 1392.880 0.9557115 1.002938 0.085 ns
STOP/SCOPE (GDM) 0.9790400 0.0120362 1392.880 0.9557115 1.002938 0.085 ns
GDM/Uncomplicated (SCOPE) 1.0081700 0.0139300 1431.273 0.9812117 1.035869 0.556 ns
GDM/Uncomplicated (STOP) 1.0081700 0.0139300 1431.273 0.9812117 1.035869 0.556 ns
Insulin
contrast ratio SE df asymp.LCL asymp.UCL p.value
SCOPE/SCOPE (Overall) 1.0709394 0.0571774 Inf 0.9645378 1.189078 0.199 ns
STOP/SCOPE (Uncomplicated) 1.0348620 0.0276256 Inf 0.9821089 1.090449 0.199 ns
STOP/SCOPE (GDM) 1.0348620 0.0276256 Inf 0.9821089 1.090449 0.199 ns
GDM/Uncomplicated (SCOPE) 0.9703072 0.0263960 Inf 0.9199271 1.023446 0.268 ns
GDM/Uncomplicated (STOP) 0.9703072 0.0263960 Inf 0.9199271 1.023446 0.268 ns
HOMA.IR
contrast ratio SE df asymp.LCL asymp.UCL p.value
SCOPE/SCOPE (Overall) 1.0713535 0.0614462 Inf 0.9574435 1.198816 0.229 ns
STOP/SCOPE (Uncomplicated) 1.0350621 0.0296824 Inf 0.9784904 1.094904 0.229 ns
STOP/SCOPE (GDM) 1.0350621 0.0296824 Inf 0.9784904 1.094904 0.229 ns
GDM/Uncomplicated (SCOPE) 0.9694588 0.0284367 Inf 0.9152957 1.026827 0.290 ns
GDM/Uncomplicated (STOP) 0.9694588 0.0284367 Inf 0.9152957 1.026827 0.290 ns
GLUC3_mmol.L
contrast ratio SE df asymp.LCL asymp.UCL p.value
SCOPE/SCOPE (Overall) 1.006532 0.0102222 Inf 0.9866950 1.026768 0.521 ns
STOP/SCOPE (Uncomplicated) 1.003261 0.0050945 Inf 0.9933252 1.013295 0.521 ns
STOP/SCOPE (GDM) 1.003261 0.0050945 Inf 0.9933252 1.013295 0.521 ns
GDM/Uncomplicated (SCOPE) 1.001669 0.0065280 Inf 0.9889558 1.014546 0.798 ns
GDM/Uncomplicated (STOP) 1.001669 0.0065280 Inf 0.9889558 1.014546 0.798 ns

59.3.7 Diagnostics

Model diagnositcs.

Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

59.3.8 Plots